The Top Brain-Boosting Nootropics for Healthy Aging

Image by Taras Yasinski from Pixabay

Written by Katie Koschalk, a health and wellness writer, certified holistic nutritionist, and certified personal trainer based in California.

As you age, it’s natural to start thinking more seriously about brain health and how to stay sharp, focused, and mentally resilient. Nootropic supplements can play a meaningful role in that equation. 

Nootropics are natural or synthetic compounds that may help enhance brain performance—think better memory, sharper focus, improved mood, and long-term cognitive support. If you’ve ever brewed a cup of coffee to power through a late-night study session, you already understand the appeal.

But not all nootropics work the same way. While some offer a quick boost in focus or mental energy, others work behind the scenes to address deeper aspects of brain aging, such as oxidative stress, mitochondrial decline, and inflammation.

Here are the top nootropic supplements that support healthy aging, and how they may help. 

#1: Citicoline (CDP-Choline)

Citicoline is a naturally occurring compound that releases two main substances into your body: cytidine and choline. Once absorbed, they cross the blood-brain barrier and reach your central nervous system, where they produce a range of neuroprotective effects. 

Research suggests that citicoline may enhance memory and mental energy, especially in older adults. 

#2: Ergothioneine

Ergothioneine is a powerful antioxidant and amino acid that accumulates in high concentrations in the brain, where it protects neurons from oxidative stress and inflammation. 

Some studies suggest ergothioneine may help protect against cognitive decline by reducing oxidative stress in the brain, making it a promising compound for supporting cognition and brain health as you age.

MitoPrime®—an ingredient found in premium longevity supplements—makes it easier to tap into these benefits. Through a patented natural fermentation process, MitoPrime® offers a fermented, pure L-isomer designed for maximum potency, bioavailability, and sustainability.

#3: Lion’s Mane Mushroom

Lion’s mane is a medicinal mushroom prized for its potential to support brain health. It’s been shown to stimulate the production of nerve growth factor (NGF), a protein that helps protect and regenerate neurons.

As you get older, the brain’s ability to form new cells and connections naturally declines. Compounds in lion’s mane (hericenones and erinacines) may help counteract this process by encouraging brain cell growth. That could mean better memory, sharper thinking, and a lower risk of cognitive decline with age.

#4: Bacopa 

An herb used for centuries in Ayurvedic medicine, bacopa (Bacopa monnieri) is rich in bacosides—compounds shown to enhance cognitive performance and protect brain cells from damage. 

Research suggests that bacopa may support brain health by enhancing memory, improving the speed of information processing, and increasing learning rate. 

#5: Salidroside 

Salidroside is one of the main active compounds in Rhodiola rosea, a plant often used to help the body manage stress. But it may also have powerful brain-protective benefits. Research suggests salidroside may support cognitive function under stress and provide  neuroprotection. 

Most standardized rhodiola extracts contain just 1% salidroside, which translates to only about 3 mg per serving. In contrast, SalidroPure™ delivers 20-25 mg of pure salidroside per serving. It’s made through fermentation, allowing for consistent potency without putting pressure on endangered wild Rhodiola sources.

The Bottom Line on Nootropics for Healthy Aging 

These nootropic supplements offer promising support for cognitive function, memory, and long-term neurological resilience, especially when combined with other brain-healthy habits, such as regular exercise, adequate sleep, and a nutrient-rich diet.