Ergothioneine Benefits: 6 Ways It May Support Aging, Cognitive Function, and More

Slowing aging with L-ergothioneine

Written by Katie Koschalk, a health and wellness writer, certified holistic nutritionist, and certified personal trainer based in California.

Could a little-known nutrient found in mushrooms hold the key to a longer, healthier life? A naturally occurring compound called ergothioneine is emerging as a powerful ally in the fight against aging and cognitive decline. Researchers are uncovering its potential to protect the brain, reduce oxidative stress, and support the systems that keep you sharp and resilient as you grow older.

In this article, we’ll explore how ergothioneine works and why it’s becoming a promising candidate in the conversation about brain health and longevity.

What is Ergothioneine?

Ergothioneine is a natural compound found in certain foods, especially mushrooms. The body has a special transporter that absorbs ergothioneine from your diet and delivers it to areas under high oxidative stress, like the brain, liver, and eyes, where cells are more prone to damage over time.

What Are the Potential Benefits of Ergothioneine?

Ergothioneine has been studied for a wide range of health benefits. Here are some of the key ways ergothioneine may help:

#1: Brain Health Support

Ergothioneine can cross the blood-brain barrier and builds up in brain areas most prone to damage. Research suggests it helps protect brain cells from oxidative stress—cell damage caused by too many harmful molecules called free radicals and not enough antioxidants to counter them.

It may also help defend the brain against inflammation and toxins linked to age-related cognitive decline, and has been shown to improve memory and learning in animal studies.

#2: Antioxidant Power

Ergothioneine scavenges a wide range of harmful free radicals that can damage cells, and is even more effective than glutathione in some cases. What’s more, unlike many antioxidants, it’s incredibly stable, meaning it doesn’t break down easily, which helps it stay effective in the body.

#3: Inflammation Reduction

Studies suggest ergothioneine can reduce the activity of inflammatory molecules and protect against inflammation-related damage. This may be especially important for chronic conditions where ongoing inflammation plays a key role.

#4: Eyes and Skin Protection

Ergothioneine accumulates in tissues like the lens of the eye and the skin, where it helps protect against UV damage. In fact, it’s even included in some skincare products for its anti-aging and protective effects.

#5: Heart Health Support

Ergothioneine has shown promise in supporting heart health. It reduces oxidative stress in the cardiovascular system and helps maintain the function of blood vessel linings. It also helps the heart’s cells make energy and stay strong, especially during times of stress.

#6: Healthy Aging and Longevity

Lower ergothioneine levels have been linked to slower walking speed, frailty, and cognitive decline. Since ergothioneine helps protect cells from damage, increasing your levels may support healthy aging and help guard against age-related diseases.

How Can You Get Ergothioneine?

Since your body can’t make ergothioneine on its own, you have to get it from your diet. The best natural sources are mushrooms, especially varieties like king oyster, porcini, shiitake, and enoki.

You can also find smaller amounts in other foods, including red meat, garlic, nuts, milk, oats, and black beans.

If you want to increase your intake, ergothioneine is also available in supplement form. One of the most advanced options is MitoPrime®, a highly purified form of L-ergothioneine. Made with a patented natural fermentation process, it yields a 99% pure L-isomer, ensuring maximum potency and bioavailability.

The Bottom Line on Ergothioneine Benefits

Ergothioneine may not be a household name (yet), but the science behind it is compelling. From its powerful antioxidant and anti-inflammatory properties to its ability to cross the blood-brain barrier and protect cells in high-stress areas, this unique compound shows promise in supporting brain health, healthy aging, and overall vitality.